Version 5.4
Bos taurus Protein: ENSA
Summary
InnateDB Protein IDBP-685046.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENSA
Protein Name alpha-endosulfine
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009379
InnateDB Gene IDBG-633348 (ENSA)
Protein Structure
UniProt Annotation
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004864 protein phosphatase inhibitor activity
GO:0005102 receptor binding
GO:0008601 protein phosphatase type 2A regulator activity
GO:0019212 phosphatase inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0051721 protein phosphatase 2A binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0043086 negative regulation of catalytic activity
GO:0050790 regulation of catalytic activity
GO:0050796 regulation of insulin secretion
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006760 Endosulphine
PFAM PF04667
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P68210
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281142
UniGene Bt.29968
RefSeq XP_005197782
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ005986 BC112682 X95958
GenPept AAI12683 CAA06800 CAA65196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca