Version 5.4
Bos taurus Protein: SERGEF
Summary
InnateDB Protein IDBP-683965.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERGEF
Protein Name Secretion-regulating guanine nucleotide exchange factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007022
InnateDB Gene IDBG-632360 (SERGEF)
Protein Structure
UniProt Annotation
Function Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0043547 positive regulation of GTPase activity
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PRINTS PR00633
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3MHW0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534377
UniGene Bt.1247
RefSeq NP_001069489
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104610
GenPept AAI04611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca