InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde2a

Summary

InnateDB Protein

IDBP-625960.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde2a

Protein Name

phosphodiesterase 2A, cGMP-stimulated

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131553

InnateDB Gene

IDBG-202048 (Pde2a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0030552	cAMP binding
GO:0030553	cGMP binding
GO:0030911	TPR domain binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0019933	cAMP-mediated signaling
GO:0019934	cGMP-mediated signaling
GO:0030224	monocyte differentiation
GO:0033159	negative regulation of protein import into nucleus, translocation
GO:0035690	cellular response to drug
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043116	negative regulation of vascular permeability
GO:0043117	positive regulation of vascular permeability
GO:0046069	cGMP catabolic process
GO:0071321	cellular response to cGMP
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2446107

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt