InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE8A

Summary

InnateDB Protein

IDBP-596806.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE8A

Protein Name

phosphodiesterase 8A

Synonyms

HsT19550;

Species

Homo sapiens

Ensembl Protein

ENSP00000432309

InnateDB Gene

IDBG-27887 (PDE8A)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. {ECO:0000269PubMed:18983167}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0009187	cyclic nucleotide metabolic process
GO:0035556	intracellular signal transduction