Version 5.4
Homo sapiens Protein: SERPINB7
Summary
InnateDB Protein IDBP-584950.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB7
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 7
Synonyms MEGSIN; PPKN; TP55;
Species Homo sapiens
Ensembl Protein ENSP00000444861
InnateDB Gene IDBG-4531 (SERPINB7)
Protein Structure
UniProt Annotation
Function Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations Keratoderma, palmoplantar, Nagashima type (PPKN) [MIM:615598]: An autosomal recessive, non-syndromic, diffuse palmoplantar keratosis characterized by well-demarcated diffuse erythematous hyperkeratosis expanding onto the dorsal surfaces of the palms and feet and the Achilles tendon area. Hyperkeratosis is mild and non-progressive. {ECO:0000269PubMed:24207119}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body. {ECO:0000269PubMed:24207119}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75635
PhosphoSite PhosphoSite-O75635
TrEMBL Q6MZG5
UniProt Splice Variant
Entrez Gene 8710
UniGene Hs.742388
RefSeq NP_001248759
HUGO HGNC:13902
OMIM 603357
CCDS CCDS11988
HPRD 04524
IMGT
EMBL AC069356 AC072051 AF027866 AK300828 BC069417 BC069442 BC069547 BC106743 BC106744 BX641156 D88575
GenPept AAC64506 AAH69417 AAH69442 AAH69547 AAI06744 AAI06745 BAA31232 BAG62480 CAE46069

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca