Version 5.4
Mus musculus Protein: Pla2g4b
Summary
InnateDB Protein IDBP-542490.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g4b
Protein Name phospholipase A2, group IVB (cytosolic)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000118458
InnateDB Gene IDBG-200348 (Pla2g4b)
Protein Structure
UniProt Annotation
Function Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID MGI:2384819
InterPro IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
PFAM PF00168
PF01735
PRINTS PR00360
PIRSF
SMART SM00239
SM00022
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0C871
PhosphoSite PhosphoSite-P0C871
TrEMBL Q06G06
UniProt Splice Variant
Entrez Gene 211429
UniGene Mm.487667
RefSeq NP_663353
MGI ID
MGI Symbol Pla2g4b
OMIM
CCDS CCDS38209
HPRD
IMGT
EMBL AB195274 AB195275 AL833774 BC042758 BC098210 DQ888308
GenPept AAH42758 ABI53032 BAH36747 BAH36748 CAM22684

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca