InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sbf1

Summary

InnateDB Protein

IDBP-540089.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sbf1

Protein Name

SET binding factor 1

Synonyms

2610510A08Rik; B230113C15Rik; mKIAA3020; Mtmr5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120725

InnateDB Gene

IDBG-173400 (Sbf1)

Protein Structure

UniProt Annotation

Function

Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. Alternatively proposed to function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001691	pseudophosphatase activity
GO:0016791	phosphatase activity
GO:0017112	Rab guanyl-nucleotide exchange factor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0007283	spermatogenesis
GO:0016311	dephosphorylation
GO:0032313	regulation of Rab GTPase activity
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1925230

InterPro

IPR001194 DENN domain
IPR001849 Pleckstrin homology domain
IPR004182 GRAM domain
IPR005112 dDENN domain
IPR005113 uDENN domain
IPR010569 Myotubularin-like phosphatase domain
IPR022096 Myotubularin protein
IPR029021 Protein-tyrosine phosphatase-like

PFAM