InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dad1

Summary

InnateDB Protein

IDBP-537646.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dad1

Protein Name

defender against cell death 1

Synonyms

AI323713;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122366

InnateDB Gene

IDBG-160827 (Dad1)

Protein Structure

UniProt Annotation

Function

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (By similarity). Loss of the DAD1 protein triggers apoptosis. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process

GO:0001824	blastocyst development
GO:0006486	protein glycosylation
GO:0006915	apoptotic process
GO:0007584	response to nutrient
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process