Version 5.4
Homo sapiens Protein: VWCE
Summary
InnateDB Protein IDBP-49890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VWCE
Protein Name von Willebrand factor C and EGF domains
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000301770
InnateDB Gene IDBG-49886 (VWCE)
Protein Structure
UniProt Annotation
Function May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma. {ECO:0000269PubMed:16496348}.
Subcellular Localization Secreted {ECO:0000305}. Note=According to PubMed:16496348 is localized in the cytoplasm. {ECO:0000269PubMed:16496348}.
Disease Associations
Tissue Specificity Expressed in liver. {ECO:0000269PubMed:16496348}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
PFAM PF00008
PF07645
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96DN2
PhosphoSite PhosphoSite-Q96DN2
TrEMBL
UniProt Splice Variant
Entrez Gene 220001
UniGene Hs.60640
RefSeq
HUGO HGNC:26487
OMIM 611115
CCDS
HPRD 08116
IMGT
EMBL AK056571 AY205235 BC052564 BC077719 BC142624 CH471076
GenPept AAI42625 AAO47606 BAB71219 EAW73932

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca