InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GCC2

Summary

InnateDB Protein

IDBP-484532.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GCC2

Protein Name

GRIP and coiled-coil domain containing 2

Synonyms

GCC185; RANBP2L4; REN53;

Species

Homo sapiens

Ensembl Protein

ENSP00000419969

InnateDB Gene

IDBG-65024 (GCC2)

Protein Structure

UniProt Annotation

Function

Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269PubMed:16885419, ECO:0000269PubMed:17488291, ECO:0000269PubMed:17543864}.

Subcellular Localization

Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11149944}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006622	protein targeting to lysosome
GO:0031023	microtubule organizing center organization
GO:0034067	protein localization to Golgi apparatus
GO:0034453	microtubule anchoring
GO:0034499	late endosome to Golgi transport
GO:0042147	retrograde transport, endosome to Golgi
GO:0070861	regulation of protein exit from endoplasmic reticulum
GO:0071955	recycling endosome to Golgi transport
GO:0090161	Golgi ribbon formation