InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIPARP

Summary

InnateDB Protein

IDBP-475893.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIPARP

Protein Name

TCDD-inducible poly(ADP-ribose) polymerase

Synonyms

ARTD14; PARP7; pART14;

Species

Homo sapiens

Ensembl Protein

ENSP00000418757

InnateDB Gene

IDBG-62730 (TIPARP)

Protein Structure

UniProt Annotation

Function

Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of ADP-ribosylation leads to the formation of poly(ADPribose) chains on the protein, thereby altering the function of the target protein. May play a role in the adaptive response to chemical exposure (TCDD) and thereby mediates certain effects of the chemicals (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003950	NAD+ ADP-ribosyltransferase activity
GO:0035326	enhancer binding
GO:0046872	metal ion binding

Biological Process

GO:0010629	negative regulation of gene expression
GO:0045732	positive regulation of protein catabolic process
GO:0071407	cellular response to organic cyclic compound