InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLS2

Summary

InnateDB Protein

IDBP-41156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLS2

Protein Name

glutaminase 2 (liver, mitochondrial)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310447

InnateDB Gene

IDBG-41154 (GLS2)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269PubMed:20378837}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:20378837}.

Disease Associations

Tissue Specificity

Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269PubMed:10620514, ECO:0000269PubMed:20378837}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004359	glutaminase activity
GO:0005515	protein binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0006541	glutamine metabolic process
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0008652	cellular amino acid biosynthetic process
GO:0014047	glutamate secretion
GO:0034641	cellular nitrogen compound metabolic process
GO:0042981	regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0072593	reactive oxygen species metabolic process