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InnateDB Protein
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IDBP-387413.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HENMT1
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Protein Name
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HEN1 methyltransferase homolog 1 (Arabidopsis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000403953
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InnateDB Gene
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IDBG-100681 (HENMT1)
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Protein Structure
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| Function |
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
3
[view]
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| Protein-Protein |
3
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q5T8I9
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| TrEMBL |
X6RGV9
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| UniProt Splice Variant |
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| Entrez Gene |
113802
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| UniGene |
Hs.7962
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| RefSeq |
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| HUGO |
HGNC:26400
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| OMIM |
612178
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| CCDS |
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| HPRD |
08086
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| IMGT |
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| EMBL |
AL160171
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| GenPept |
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Version 5.4