InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH2D3C

Summary

InnateDB Protein

IDBP-381009.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2D3C

Protein Name

SH2 domain containing 3C

Synonyms

CHAT; NSP3; PRO34088; SHEP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000388536

InnateDB Gene

IDBG-86372 (SH2D3C)

Protein Structure

UniProt Annotation

Function

Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10187783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	11 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007254	JNK cascade
GO:0007264	small GTPase mediated signal transduction
GO:0009967	positive regulation of signal transduction
GO:0043547	positive regulation of GTPase activity