Version 5.4
Homo sapiens Protein: TTLL8
Summary
InnateDB Protein IDBP-380533.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTLL8
Protein Name tubulin tyrosine ligase-like family, member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392252
InnateDB Gene IDBG-12751 (TTLL8)
Protein Structure
UniProt Annotation
Function Monoglycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016989 sigma factor antagonist activity
GO:0070735 protein-glycine ligase activity
GO:0070736 protein-glycine ligase activity, initiating
Biological Process
GO:0006464 cellular protein modification process
GO:0018094 protein polyglycylation
GO:0042384 cilium assembly
Cellular Component
GO:0005874 microtubule
GO:0005929 cilium
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
IPR005572 Anti sigma-E protein RseA, N-terminal
PFAM PF03133
PF03872
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6PVC2
PhosphoSite PhosphoSite-A6PVC2
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.731315
RefSeq
HUGO HGNC:34000
OMIM
CCDS
HPRD
IMGT
EMBL AL022327 CR745100
GenPept CAO03520

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca