Version 5.4
Homo sapiens Protein: DMKN
Summary
InnateDB Protein IDBP-378078.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMKN
Protein Name dermokine
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392222
InnateDB Gene IDBG-44316 (DMKN)
Protein Structure
UniProt Annotation
Function May act as a soluble regulator of keratinocyte differentiation. {ECO:0000305}.
Subcellular Localization Secreted {ECO:0000269PubMed:15234001}.
Disease Associations
Tissue Specificity Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis. {ECO:0000269PubMed:16374476, ECO:0000269PubMed:17380110}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6E0U4
PhosphoSite PhosphoSite-Q6E0U4
TrEMBL R4GMQ0
UniProt Splice Variant
Entrez Gene 93099
UniGene Hs.417795
RefSeq NP_001119531
HUGO HGNC:25063
OMIM
CCDS CCDS46051
HPRD 12387
IMGT
EMBL AC138125 AD001502 AY358412 AY622964 AY622965 AY789695 AY789696 AY789697 AY789698 AY789699 AY789700 AY789701 AY789702 AY789703 AY789704 AY789705 AY789706 AY789707 BC004493 BC011886 BC035311 EF158319 EF158320 EF158321 EF158322 EF158323
GenPept AAH04493 AAH11886 AAH35311 AAQ88778 AAT68268 AAT68269 AAX48745 AAX48746 AAX48747 AAX48748 AAX48749 AAX48750 AAX48751 AAX48752 AAX48753 AAX48754 AAX48755 AAX48756 AAX48757 ABN11271 ABN11272 ABN11273 ABN11274 ABN11275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca