Version 5.4
Homo sapiens Protein: PLVAP
Summary
InnateDB Protein IDBP-36594.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLVAP
Protein Name plasmalemma vesicle associated protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252590
InnateDB Gene IDBG-36592 (PLVAP)
Protein Structure
UniProt Annotation
Function Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. {ECO:0000269PubMed:15155804}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Membrane- associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. {ECO:0000269PubMed:11401446, ECO:0000269PubMed:15971170}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000165 MAPK cascade
GO:0002693 positive regulation of cellular extravasation
GO:0033209 tumor necrosis factor-mediated signaling pathway
Cellular Component
GO:0005901 caveola
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR009538 PV-1
PFAM PF06637
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BX97
PhosphoSite PhosphoSite-Q9BX97
TrEMBL
UniProt Splice Variant
Entrez Gene 83483
UniGene Hs.107125
RefSeq NP_112600
HUGO HGNC:13635
OMIM 607647
CCDS CCDS32952
HPRD 09626
IMGT
EMBL AF326591 AF348827 AK074054 AK096030 AL834363 BC050365 BC056414
GenPept AAH50365 AAH56414 AAK11226 AAK20040 BAB84880 BAC04681 CAD39027

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca