InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PNPLA8

Summary

InnateDB Protein

IDBP-36338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PNPLA8

Protein Name

patatin-like phospholipase domain containing 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257694

InnateDB Gene

IDBG-36334 (PNPLA8)

Protein Structure

UniProt Annotation

Function

Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. {ECO:0000269PubMed:10744668, ECO:0000269PubMed:15695510}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart. {ECO:0000269PubMed:10744668, ECO:0000269PubMed:10833412, ECO:0000269PubMed:15629460, ECO:0000269PubMed:15695510}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0005488	binding
GO:0005524	ATP binding
GO:0047499	calcium-independent phospholipase A2 activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006644	phospholipid metabolic process
GO:0008152	metabolic process
GO:0008219	cell death
GO:0019369	arachidonic acid metabolic process
GO:0034638	phosphatidylcholine catabolic process
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0043651	linoleic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0046338	phosphatidylethanolamine catabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0050482	arachidonic acid secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm