Version 5.4
Homo sapiens Protein: SERGEF
Summary
InnateDB Protein IDBP-34370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERGEF
Protein Name secretion regulating guanine nucleotide exchange factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265965
InnateDB Gene IDBG-34368 (SERGEF)
Protein Structure
UniProt Annotation
Function Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10571079}. Nucleus {ECO:0000269PubMed:10571079}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0032853 positive regulation of Ran GTPase activity
GO:0050709 negative regulation of protein secretion
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PRINTS PR00633
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGK8
PhosphoSite PhosphoSite-Q9UGK8
TrEMBL E9PS70
UniProt Splice Variant
Entrez Gene 26297
UniGene Hs.32470
RefSeq NP_036271
HUGO HGNC:17499
OMIM 606051
CCDS CCDS7828
HPRD 06926
IMGT
EMBL AC055860 AC124058 AC124078 AJ243950 AJ243951 BC065375
GenPept AAH65375 CAB60832 CAB60833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca