InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MUC12

Summary

InnateDB Protein

IDBP-32837.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MUC12

Protein Name

mucin 12, cell surface associated

Synonyms

MUC-11; MUC-12; MUC11;

Species

Homo sapiens

Ensembl Protein

ENSP00000368755

InnateDB Gene

IDBG-32833 (MUC12)

Protein Structure

UniProt Annotation

Function

Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium. {ECO:0000269PubMed:17058067}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous, with higher expression in colon. Down-regulated in colorectal cancer as well as in the colon of patients with ulcerative colitis (UC) and Crohn's disease (CD). {ECO:0000269PubMed:10463611, ECO:0000269PubMed:17058067}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001558	regulation of cell growth
GO:0016266	O-glycan processing
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process