Version 5.4
Homo sapiens Protein: SPZ1
Summary
InnateDB Protein IDBP-31320.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPZ1
Protein Name spermatogenic leucine zipper 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369611
InnateDB Gene IDBG-31318 (SPZ1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Specifically and strongly expressed in the testis. Expressed in several tumor cell lines. {ECO:0000269PubMed:12778315, ECO:0000269PubMed:15899793}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXG8
PhosphoSite PhosphoSite-Q9BXG8
TrEMBL D6RFL8
UniProt Splice Variant
Entrez Gene 84654
UniGene Hs.519403
RefSeq NP_115956
HUGO HGNC:30721
OMIM
CCDS CCDS43336
HPRD 15440
IMGT
EMBL AC026410 AF333098 AK098575 AK314007 BC033798 CH471084
GenPept AAH33798 AAK17995 BAC05340 BAG36718 EAW95848

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca