InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLRC1

Summary

InnateDB Protein

IDBP-294829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLRC1

Protein Name

killer cell lectin-like receptor subfamily C, member 1

Synonyms

CD159A; NKG2; NKG2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000385304

InnateDB Gene

IDBG-19034 (KLRC1)

Protein Structure

UniProt Annotation

Function

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Natural killer cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0030246	carbohydrate binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0050776	regulation of immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001304 C-type lectin
IPR008646 Herpesvirus UL45-like
IPR016187 C-type lectin fold

PFAM

PF00059
PF05473

PRINTS

PIRSF

SMART

SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P26715

PhosphoSite

PhosphoSite-P26715

TrEMBL

UniProt Splice Variant

Entrez Gene

3821

UniGene

Hs.512576

RefSeq

NP_998822

HUGO

HGNC:6374

OMIM

161555

CCDS

CCDS8626

HPRD

01192

IMGT

EMBL

AC068775 AF023840 AF461812 BC012550 BC053840 U54783 U54784 U54785 U54786 X54867 X54868

GenPept

AAB17133 AAC17488 AAH12550 AAH53840 AAL65234 CAA38649 CAA38650