InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE8A

Summary

InnateDB Protein

IDBP-27891.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE8A

Protein Name

phosphodiesterase 8A

Synonyms

HsT19550;

Species

Homo sapiens

Ensembl Protein

ENSP00000340679

InnateDB Gene

IDBG-27887 (PDE8A)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. {ECO:0000269PubMed:18983167}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0009187	cyclic nucleotide metabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF13188
PF13426
PF00072
PF00233

PRINTS

PR00387

PIRSF

SMART

SM00091
SM00448
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt