Version 5.4
Homo sapiens Protein: WHAMM
Summary
InnateDB Protein IDBP-26812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WHAMM
Protein Name WAS protein homolog associated with actin, golgi membranes and microtubules
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000286760
InnateDB Gene IDBG-26810 (WHAMM)
Protein Structure
UniProt Annotation
Function Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. {ECO:0000269PubMed:18614018}.
Subcellular Localization Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules.
Disease Associations
Tissue Specificity Expressed in brain, lung, heart, colon and kidney (at protein level).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003779 actin binding
Biological Process
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0030659 cytoplasmic vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR003124 WH2 domain
IPR010978 tRNA-binding arm
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TF30
PhosphoSite PhosphoSite-Q8TF30
TrEMBL
UniProt Splice Variant
Entrez Gene 123720
UniGene Hs.377360
RefSeq NP_001073904
HUGO HGNC:30493
OMIM 612393
CCDS CCDS45333
HPRD
IMGT
EMBL AB075851 AC044907 AK097947
GenPept BAB85557 BAC05201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca