Version 5.4
Mus musculus Protein: Nit1
Summary
InnateDB Protein IDBP-258447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nit1
Protein Name nitrilase 1
Synonyms AI255805; ESTM30; W57327;
Species Mus musculus
Ensembl Protein ENSMUSP00000106920
InnateDB Gene IDBG-204444 (Nit1)
Protein Structure
UniProt Annotation
Function Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T- cells. Has apparently no omega-amidase activity such as NIT2. {ECO:0000269PubMed:16864578, ECO:0000269PubMed:19395373, ECO:0000269PubMed:19479888, ECO:0000269PubMed:19595734, ECO:0000269PubMed:19596042}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19479888}. Mitochondrion {ECO:0000269PubMed:19479888}.
Disease Associations
Tissue Specificity Expressed in most tissues with higher expression in adult liver and kidney as well as in fetal adrenal gland and skeletal muscle. {ECO:0000269PubMed:16864578, ECO:0000269PubMed:9671749}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006807 nitrogen compound metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1350916
InterPro IPR003010 Carbon-nitrogen hydrolase
PFAM PF00795
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VDK1
PhosphoSite PhosphoSite-Q8VDK1
TrEMBL D3Z3I3
UniProt Splice Variant
Entrez Gene 27045
UniGene Mm.472271
RefSeq NP_001229509
MGI ID
MGI Symbol Nit1
OMIM
CCDS CCDS56656
HPRD
IMGT
EMBL AC084821 AC087229 AF069985 AF069988 BC021634
GenPept AAC40184 AAC40185 AAH21634

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca