Version 5.4
Mus musculus Protein: Prdm6
Summary
InnateDB Protein IDBP-249729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdm6
Protein Name PR domain containing 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000111057
InnateDB Gene IDBG-147047 (Prdm6)
Protein Structure
UniProt Annotation
Function Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to PubMed:16537907, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to PubMed:17662997, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. {ECO:0000269PubMed:16537907, ECO:0000269PubMed:17662997}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16537907, ECO:0000269PubMed:17662997}.
Disease Associations
Tissue Specificity Expressed in a variety of smooth muscle- containing tissues and displays especially robust expression in the cardiac outflow tract and descending aorta during embryogenesis. Also enriched in vascular precursors during development. {ECO:0000269PubMed:16537907, ECO:0000269PubMed:17662997}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0022008 neurogenesis
GO:0034968 histone lysine methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051151 negative regulation of smooth muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2684938
InterPro IPR001214 SET domain
IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00856
PF00096
PRINTS
PIRSF
SMART SM00317
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UZD5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 225518
UniGene Mm.297645
RefSeq
MGI ID
MGI Symbol Prdm6
OMIM
CCDS
HPRD
IMGT
EMBL AK133910 AK135836 AK135840 BC139295 DQ340564 DQ340565
GenPept AAI39296 ABC69307 ABC69308 BAE21922 BAE22684 BAE22688

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca