Version 5.4
Homo sapiens Protein: FITM2
Summary
InnateDB Protein IDBP-236688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FITM2
Protein Name fat storage-inducing transmembrane protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380037
InnateDB Gene IDBG-76450 (FITM2)
Protein Structure
UniProt Annotation
Function Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269PubMed:18160536, ECO:0000269PubMed:21834987}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18160536}; Multi-pass membrane protein {ECO:0000269PubMed:18160536}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:18160536}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007010 cytoskeleton organization
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010890 positive regulation of sequestering of triglyceride
GO:0022604 regulation of cell morphogenesis
GO:0034389 lipid particle organization
GO:0035356 cellular triglyceride homeostasis
Cellular Component
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR019388 Fat storage-inducing transmembrane protein
PFAM PF10261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N6M3
PhosphoSite PhosphoSite-Q8N6M3
TrEMBL
UniProt Splice Variant
Entrez Gene 128486
UniGene Hs.612926
RefSeq NP_001073941
HUGO HGNC:16135
OMIM 612029
CCDS CCDS33473
HPRD
IMGT
EMBL AL117382 BC029662 BC130446 BC136640 CH471077
GenPept AAI30447 AAI36641 CAI23111 EAW75929

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca