Version 5.4
Homo sapiens Protein: SEPT10
Summary
InnateDB Protein IDBP-234714.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEPT10
Protein Name septin 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000380826
InnateDB Gene IDBG-65245 (SEPT10)
Protein Structure
UniProt Annotation
Function Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). {ECO:0000305}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12711328}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Using a GFP-fusion protein, detected in the nucleus. {ECO:0000269PubMed:12711328}.
Disease Associations
Tissue Specificity Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines. {ECO:0000269PubMed:12711328, ECO:0000269PubMed:15915442}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005525 GTP binding
Biological Process
GO:0007049 cell cycle
GO:0051301 cell division
Cellular Component
GO:0031105 septin complex
Protein Structure and Domains
PDB ID
InterPro IPR000038 Cell division protein GTP binding
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00735
PRINTS
PIRSF PIRSF006698
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P0V9
PhosphoSite PhosphoSite-Q9P0V9
TrEMBL Q9H9P7
UniProt Splice Variant
Entrez Gene 151011
UniGene Hs.596880
RefSeq NP_848699
HUGO HGNC:14349
OMIM 611737
CCDS CCDS42726
HPRD 15325
IMGT
EMBL AC011753 AC140485 AF146760 AK021681 AK022682 AK092033 BC020502 BC050345 CH471182
GenPept AAF67469 AAH20502 AAH50345 AAY24142 BAB13873 BAB14176 BAG52471 EAW53864

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca