Version 5.4
Mus musculus Protein: Spag4
Summary
InnateDB Protein IDBP-210796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spag4
Protein Name sperm associated antigen 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036484
InnateDB Gene IDBG-210794 (Spag4)
Protein Structure
UniProt Annotation
Function May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 1: Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250}. Note=In spermatids, isoform 1 is localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is testis specific and is exclusively expressed in spermatids. {ECO:0000269PubMed:10373309}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2444120
InterPro IPR008979 Galactose-binding domain-like
IPR012919 Sad1/UNC-like, C-terminal
PFAM PF07738
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJF2
PhosphoSite PhosphoSite-
TrEMBL Q3B7Z4
UniProt Splice Variant
Entrez Gene 245865
UniGene Mm.404739
RefSeq NP_631890
MGI ID
MGI Symbol Spag4
OMIM
CCDS CCDS50777
HPRD
IMGT
EMBL AB041554 AL833786 BB610287 BC107321 BU937622 CA466584 CH466551
GenPept AAI07322 BAA95039 CAM46026 EDL06167

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca