InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr12

Summary

InnateDB Protein

IDBP-208855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr12

Protein Name

G-protein coupled receptor 12

Synonyms

Gpcr01; Gpcr12; Gpcr20; Gpcr21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038245

InnateDB Gene

IDBG-208853 (Gpr12)

Protein Structure

UniProt Annotation

Function

Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production (By similarity). Promotes neurite outgrowth and blocks myelin inhibition in neurons. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed predominantly in the forebrain and a lesser extent in the hindbrain. Lower expression in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0031210	phosphatidylcholine binding

Biological Process

GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:101909

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000599 G protein-coupled receptor 12
IPR000723 G protein-coupled receptor 3/6/12 orphan
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00650
PR00644

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35412