InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp2r1

Summary

InnateDB Protein

IDBP-207255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2r1

Protein Name

cytochrome P450, family 2, subfamily r, polypeptide 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032908

InnateDB Gene

IDBG-207253 (Cyp2r1)

Protein Structure

UniProt Annotation

Function

Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3). {ECO:0000269PubMed:12867411}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in the liver and testis. {ECO:0000269PubMed:12867411}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0030343	vitamin D3 25-hydroxylase activity
GO:0047749	cholestanetriol 26-monooxygenase activity

Biological Process

GO:0010164	response to cesium ion
GO:0010212	response to ionizing radiation
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0055114	oxidation-reduction process