Version 5.4
Mus musculus Protein: Ipo7
Summary
InnateDB Protein IDBP-206415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ipo7
Protein Name importin 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081782
InnateDB Gene IDBG-206413 (Ipo7)
Protein Structure
UniProt Annotation
Function Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. {ECO:0000250, ECO:0000269PubMed:11493596}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0042393 histone binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006886 intracellular protein transport
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:2152414
InterPro IPR001494 Importin-beta, N-terminal domain
IPR013713 Exportin/Importin, Cse1-like
IPR016024 Armadillo-type fold
PFAM PF03810
PF08506
PRINTS
PIRSF
SMART SM00913
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPL8
PhosphoSite PhosphoSite-Q9EPL8
TrEMBL
UniProt Splice Variant
Entrez Gene 233726
UniGene
RefSeq NP_852658
MGI ID
MGI Symbol Ipo7
OMIM
CCDS CCDS40085
HPRD
IMGT
EMBL AJ278435 AK039534 AK053498 AY316153 BC053524 BC064825
GenPept AAH53524 AAH64825 AAP79888 BAC30376 BAC35405 CAC17143

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca