InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spaca3

Summary

InnateDB Protein

IDBP-204395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spaca3

Protein Name

sperm acrosome associated 3

Synonyms

1700025M08Rik; ALLP17; Lyc3; mSLLP1; SLLP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099512

InnateDB Gene

IDBG-204393 (Spaca3)

Protein Structure

UniProt Annotation

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305PubMed:15982649}; Single-pass type II membrane protein {ECO:0000305PubMed:15982649}. Note=Anterior acrosome in non-capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

The processed form is expressed in sperm (at protein level). Expressed strongly in testis and epididymis and weakly in pancreas. {ECO:0000269PubMed:15982649, ECO:0000269PubMed:16014814}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity
GO:0005515	protein binding

Biological Process

GO:0016998	cell wall macromolecule catabolic process
GO:0035036	sperm-egg recognition

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002080	acrosomal membrane
GO:0005576	extracellular region
GO:0005764	lysosome
GO:0016021	integral component of membrane
GO:0030141	secretory granule

Protein Structure and Domains

PDB ID

MGI:1922872

InterPro

IPR000974 Glycoside hydrolase, family 22, lysozyme
IPR001916 Glycoside hydrolase, family 22
IPR023346 Lysozyme-like domain

PFAM

PF00062
PF13406

PRINTS

PR00137
PR00135

PIRSF

SMART

SM00263

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D9X8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

75622

UniGene

RefSeq

MGI ID

MGI Symbol

Spaca3

OMIM

CCDS

CCDS25136

HPRD

IMGT

EMBL

AK006357 AL645842 AY572448 AY601763 BC100503

GenPept

AAI00504 AAS77887 AAT07446 BAB24544 CAI24498