Version 5.4
| Mus musculus Protein: Gls2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-196802.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Gls2 | ||||||||
| Protein Name | glutaminase 2 (liver, mitochondrial) | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000047376 | ||||||||
| InnateDB Gene | IDBG-196800 (Gls2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Mitochondrion {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2143539 | ||||||||
| InterPro |
IPR002110
Ankyrin repeat IPR012338 Beta-lactamase/transpeptidase-like IPR015868 Glutaminase IPR020683 Ankyrin repeat-containing domain |
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| PFAM |
PF00023
PF13606 PF04960 PF11929 PF12796 |
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| PRINTS |
PR01415
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| PIRSF | |||||||||
| SMART |
SM00248
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q571F8 | ||||||||
| PhosphoSite | PhosphoSite-Q571F8 | ||||||||
| TrEMBL | Q3TGF1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 216456 | ||||||||
| UniGene | Mm.30102 | ||||||||
| RefSeq | NP_001028436 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Gls2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS24263 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK165896 AK168761 AK220231 BC141115 | ||||||||
| GenPept | AAI41116 BAD90156 BAE38445 BAE40597 | ||||||||