Version 5.4
| Mus musculus Protein: Gfra2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-179522.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Gfra2 | ||||||||
| Protein Name | glial cell line derived neurotrophic factor family receptor alpha 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000022699 | ||||||||
| InnateDB Gene | IDBG-179520 (Gfra2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the spleen and in the adrenal gland. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1195462 | ||||||||
| InterPro |
IPR003438
Glial cell line-derived neurotrophic factor receptor IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2 IPR016017 GDNF/GAS1 IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2 |
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| PFAM |
PF02351
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| PRINTS |
PR01316
PR01318 |
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| PIRSF |
PIRSF038071
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| SMART |
SM00907
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O08842 | ||||||||
| PhosphoSite | PhosphoSite-O08842 | ||||||||
| TrEMBL | Q3UET6 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14586 | ||||||||
| UniGene | Mm.32619 | ||||||||
| RefSeq | NP_032141 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Gfra2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS27263 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC124202 AF002701 AK138512 AK149349 BC138561 CH466535 | ||||||||
| GenPept | AAC53548 AAI38562 BAE23689 BAE28825 EDL35876 | ||||||||