InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flcn

Summary

InnateDB Protein

IDBP-179439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flcn

Protein Name

folliculin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099758

InnateDB Gene

IDBG-179437 (Flcn)

Protein Structure

UniProt Annotation

Function

May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001932	regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0007043	cell-cell junction assembly
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010823	negative regulation of mitochondrion organization
GO:0016525	negative regulation of angiogenesis
GO:0030097	hemopoiesis
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031929	TOR signaling
GO:0032006	regulation of TOR signaling
GO:0032007	negative regulation of TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0032465	regulation of cytokinesis
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035065	regulation of histone acetylation
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051898	negative regulation of protein kinase B signaling
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1900181	negative regulation of protein localization to nucleus
GO:1901723	negative regulation of cell proliferation involved in kidney development
GO:1901856	negative regulation of cellular respiration
GO:1901859	negative regulation of mitochondrial DNA metabolic process
GO:1901862	negative regulation of muscle tissue development
GO:1901874	negative regulation of post-translational protein modification
GO:2000506	negative regulation of energy homeostasis
GO:2000973	regulation of pro-B cell differentiation
GO:2001170	negative regulation of ATP biosynthetic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway