Version 5.4
Mus musculus Protein: Spz1
Summary
InnateDB Protein IDBP-172245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spz1
Protein Name spermatogenic leucine zipper 1
Synonyms 1700027M20Rik; AI429130;
Species Mus musculus
Ensembl Protein ENSMUSP00000054083
InnateDB Gene IDBG-172243 (Spz1)
Protein Structure
UniProt Annotation
Function Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine- rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269PubMed:11165476, ECO:0000269PubMed:14980513, ECO:0000269PubMed:15899793}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed specifically in the testis and epidydimis. In the testis expressed in both germ cells and somatic cells (Sertoli and Leydig cells). Expressed in several tumor cell lines. {ECO:0000269PubMed:11165476, ECO:0000269PubMed:14980513, ECO:0000269PubMed:15899793}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1930801
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99MY0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 79401
UniGene Mm.23520
RefSeq NP_084513
MGI ID
MGI Symbol Spz1
OMIM
CCDS CCDS26683
HPRD
IMGT
EMBL AF271697 AK006437 BC050748
GenPept AAH50748 AAK15458 BAE43195

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca