InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Btnl2

Summary

InnateDB Protein

IDBP-171372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Btnl2

Protein Name

butyrophilin-like 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025198

InnateDB Gene

IDBG-171370 (Btnl2)

Protein Structure

UniProt Annotation

Function

Negative regulator of T-cell proliferation. {ECO:0000269PubMed:16751379, ECO:0000269PubMed:17237401}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in intestine and at reduced levels in lung and stomach. Also expressed in thymus, spleen, lymph nodes, T-cells, B-cells, and macrophages. {ECO:0000269PubMed:16751379, ECO:0000269PubMed:17237401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0042102	positive regulation of T cell proliferation
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:1900042	positive regulation of interleukin-2 secretion

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1859549

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O70355