Version 5.4
Mus musculus Protein: Ttll4
Summary
InnateDB Protein IDBP-168448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttll4
Protein Name tubulin tyrosine ligase-like family, member 4
Synonyms 4632407P03Rik; AI451681; mKIAA0173;
Species Mus musculus
Ensembl Protein ENSMUSP00000037406
InnateDB Gene IDBG-168446 (Ttll4)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies beta- tubulin and nucleosome assembly proteins NAP1 and NAP2. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. {ECO:0000269PubMed:17499049, ECO:0000269PubMed:21074048}.
Subcellular Localization Cell projection, cilium {ECO:0000269PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:17499049}. Note=Located in cilia. In some cells, also found in basal bodies.
Disease Associations
Tissue Specificity Widely expressed with highest levels in testis. {ECO:0000269PubMed:17499049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015631 tubulin binding
GO:0016874 ligase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0018095 protein polyglutamylation
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
Protein Structure and Domains
PDB ID MGI:1914784
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80UG8
PhosphoSite PhosphoSite-Q80UG8
TrEMBL
UniProt Splice Variant
Entrez Gene 67534
UniGene Mm.260714
RefSeq NP_001014974
MGI ID
MGI Symbol Ttll4
OMIM
CCDS CCDS15053
HPRD
IMGT
EMBL AK129075 AM690747 BC044790 BC085151
GenPept AAH44790 AAH85151 BAC97885 CAM84324

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca