InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: C3AR1

Summary

InnateDB Protein

IDBP-16770.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C3AR1

Protein Name

complement component 3a receptor 1

Synonyms

AZ3B; C3AR; HNFAG09;

Species

Homo sapiens

Ensembl Protein

ENSP00000302079

InnateDB Gene

IDBG-16768 (C3AR1)

Protein Structure

UniProt Annotation

Function

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004876	complement component C3a receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004943	C3a anaphylatoxin receptor activity

Biological Process

GO:0002430	complement receptor mediated signaling pathway
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008015	blood circulation
GO:0008152	metabolic process
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010759	positive regulation of macrophage chemotaxis
GO:0045766	positive regulation of angiogenesis
GO:0090023	positive regulation of neutrophil chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001274 C5a1/C5a2 anaphylatoxin chemotactic receptor
IPR001644 C3a anaphylatoxin chemotactic receptor
IPR002234 Anaphylatoxin chemotactic receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00426
PR01060
PR01104

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q16581