InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mms19

Summary

InnateDB Protein

IDBP-166721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mms19

Protein Name

MMS19 (MET18 S. cerevisiae)

Synonyms

2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; Mms19l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026168

InnateDB Gene

IDBG-166719 (Mms19)

Protein Structure

UniProt Annotation

Function

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed with higher expression in testis. {ECO:0000269PubMed:11328871}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 166 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	166 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005488	binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0006259	DNA metabolic process
GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007059	chromosome segregation
GO:0016226	iron-sulfur cluster assembly
GO:0045893	positive regulation of transcription, DNA-templated