InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Insrr

Summary

InnateDB Protein

IDBP-158708.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Insrr

Protein Name

insulin receptor-related receptor

Synonyms

Irr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029711

InnateDB Gene

IDBG-158706 (Insrr)

Protein Structure

UniProt Annotation

Function

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. {ECO:0000269PubMed:21641549}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the islets as well as in pancreatic beta-cells. {ECO:0000269PubMed:10342810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030238	male sex determination
GO:0031532	actin cytoskeleton reorganization
GO:0046777	protein autophosphorylation
GO:0071469	cellular response to alkalinity

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:1346037

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR016246 Tyrosine-protein kinase, insulin-like receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714
PF00041
PF01108
PF00757

PRINTS

PR00109

PIRSF

PIRSF000620

SMART

SM00220
SM00060
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References