InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rxfp1

Summary

InnateDB Protein

IDBP-153316.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rxfp1

Protein Name

relaxin/insulin-like family peptide receptor 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077611

InnateDB Gene

IDBG-153314 (Rxfp1)

Protein Structure

UniProt Annotation

Function

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. {ECO:0000269PubMed:15566402}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0042562	hormone binding
GO:0046872	metal ion binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007567	parturition
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization
GO:0060427	lung connective tissue development
GO:0060658	nipple morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2682211

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR008112 Relaxin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF00560
PF13504
PF13855
PF00057

PRINTS

PR00237
PR00373
PR00261
PR01739

PIRSF

SMART

SM00192
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt