InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfk

Summary

InnateDB Protein

IDBP-150856.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfk

Protein Name

riboflavin kinase

Synonyms

0610038L10Rik; AF031381; KOI-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025617

InnateDB Gene

IDBG-150854 (Rfk)

Protein Structure

UniProt Annotation

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008531	riboflavin kinase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0009231	riboflavin biosynthetic process
GO:0009398	FMN biosynthetic process
GO:0016310	phosphorylation
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0072593	reactive oxygen species metabolic process