InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt16

Summary

InnateDB Protein

IDBP-129553.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt16

Protein Name

wingless-related MMTV integration site 16

Synonyms

E130309I19Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031681

InnateDB Gene

IDBG-129551 (Wnt16)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0043616	keratinocyte proliferation
GO:0045165	cell fate commitment
GO:0046330	positive regulation of JNK cascade
GO:0046849	bone remodeling
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060548	negative regulation of cell death
GO:0090399	replicative senescence
GO:0090403	oxidative stress-induced premature senescence