InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: N6AMT1

Summary

InnateDB Protein

IDBP-1240.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

N6AMT1

Protein Name

N-6 adenine-specific DNA methyltransferase 1 (putative)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000303584

InnateDB Gene

IDBG-1238 (N6AMT1)

Protein Structure

UniProt Annotation

Function

Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269PubMed:18539146, ECO:0000269PubMed:21193388}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. {ECO:0000269PubMed:21193388}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity

Biological Process

GO:0006479	protein methylation
GO:0030307	positive regulation of cell growth

Cellular Component

GO:0005737	cytoplasm
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR004557 Eukaryotic/archaeal PrmC-related
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF05175
PF06325

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y5N5

PhosphoSite