Version 5.4
Homo sapiens Protein: ADAMDEC1
Summary
InnateDB Protein IDBP-12364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAMDEC1
Protein Name ADAM-like, decysin 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256412
InnateDB Gene IDBG-12360 (ADAMDEC1)
Protein Structure
UniProt Annotation
Function May play an important role in the control of the immune response and during pregnancy. {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC. {ECO:0000269PubMed:14632642, ECO:0000269PubMed:9271581}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0006955 immune response
GO:0007162 negative regulation of cell adhesion
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
PFAM PF01421
PF00200
PF01562
PRINTS PR00289
PIRSF
SMART SM00050
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15204
PhosphoSite PhosphoSite-
TrEMBL B7Z6U5
UniProt Splice Variant
Entrez Gene 27299
UniGene Hs.688686
RefSeq NP_055294
HUGO HGNC:16299
OMIM 606393
CCDS CCDS6044
HPRD 07070
IMGT
EMBL AC120193 AK300959 AK316320 AK316322 BC069582 BC074877 BC074878 Y13323
GenPept AAH69582 AAH74877 AAH74878 BAH13381 BAH14691 BAH14693 CAA73764

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca