InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHST15

Summary

InnateDB Gene

IDBG-92594.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHST15

Gene Name

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000182022

Encoded Proteins

IDBP-92596

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

IDBP-386656

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:124007666-124093607

Strand

Reverse strand

Band

q26.13

Transcripts

ENST00000346248	ENSP00000333947
ENST00000435907	ENSP00000402394
ENST00000476765
ENST00000462406

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008146	sulfotransferase activity
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0019319	hexose biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030206	chondroitin sulfate biosynthetic process
GO:0044281	small molecule metabolic process