Version 5.4
Homo sapiens Gene: PLA2G7
Summary
InnateDB Gene IDBG-89956.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G7
Gene Name phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms LDL-PLA2; LP-PLA2; PAFAD; PAFAH
Species Homo sapiens
Ensembl Gene ENSG00000146070
Encoded Proteins
IDBP-89958
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
IDBP-588989
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:46704201-46735693
Strand Reverse strand
Band p12.3
Transcripts
ENST00000274793 ENSP00000274793
ENST00000537365 ENSP00000445666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005543 phospholipid binding
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0016042 lipid catabolic process
GO:0034374 low-density lipoprotein particle remodeling
GO:0034440 lipid oxidation
GO:0034441 plasma lipoprotein particle oxidation
GO:0044267 cellular protein metabolic process
GO:0050729 positive regulation of inflammatory response
GO:0090026 positive regulation of monocyte chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0034362 low-density lipoprotein particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023913
View Gene Order
ENSBTAG00000019315
Not yet available
Pathways
NETPATH
REACTOME
REACT_19189
Synthesis, secretion, and deacylation of Ghrelin pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584823
RefSeq NM_001168357 NM_005084 XM_005249408
HUGO
OMIM
CCDS CCDS4917
HPRD 03407
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca