Version 5.4
Homo sapiens Gene: DOC2B
Summary
InnateDB Gene IDBG-775611.1
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOC2B
Gene Name double C2-like domains, beta
Synonyms DOC2BL
Species Homo sapiens
Ensembl Gene ENSG00000272636
Encoded Proteins
IDBP-810689
double C2-like domains, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:142789-181636
Strand Reverse strand
Band p13.3
Transcripts
ENST00000613549 ENSP00000482950
ENST00000609727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019905 syntaxin binding
Biological Process
GO:0008104 protein localization
GO:0032024 positive regulation of insulin secretion
GO:0048791 calcium ion-dependent exocytosis of neurotransmitter
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8447
UniGene
RefSeq NM_003585
HUGO HGNC:2986
OMIM 604568
CCDS CCDS73934
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 8447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca